Rejuran vs Profhilo: Which Injectable Is Better for Aging Skin?

Rejuran and Profhilo are popular injectable skin treatments in Korea for patients concerned about fine lines, dryness, loss of elasticity, and overall skin quality. However, they use different ingredients and are designed for different treatment goals.

What Is Rejuran?

Rejuran is a polynucleotide (PN)-based injectable treatment designed to support skin quality and regeneration.

Key features:

• Supports skin elasticity
• Improves skin texture
• Helps soften fine lines
• Supports overall skin quality
• Commonly used on the face

It is often chosen by patients seeking gradual improvement in skin quality and elasticity.

What Is Profhilo?

Profhilo is an injectable treatment containing high concentrations of hyaluronic acid (HA) designed to improve skin hydration and elasticity.

Key features:

• Improves skin hydration
• Supports elasticity and firmness
• Helps smooth fine lines
• Improves overall skin quality
• Provides a subtle, refreshed appearance

It can be a good option for patients looking for hydration and overall skin rejuvenation without significant added volume.

Rejuran vs Profhilo: Key Differences

• Main ingredient: Rejuran → PN; Profhilo → Hyaluronic acid
• Main focus: Rejuran → Skin quality and regeneration; Profhilo → Hydration and elasticity
• Best for: Rejuran → Texture and fine lines; Profhilo → Dryness, laxity, and overall hydration
• Treatment approach: Rejuran → Multiple small injections; Profhilo → Specific injection points
• Volume effect: Both → Designed primarily for skin quality, not traditional facial filling

The right choice depends on your main signs of skin aging.

Which Is Better for Aging Skin?

👉 Rejuran may be better for skin texture and elasticity, while Profhilo can be a stronger choice when hydration and overall skin quality are the priorities.

For example:

• Skin texture → Rejuran
• Elasticity → Rejuran
• Fine lines → Both
• Dry or dehydrated skin → Profhilo
• Hydration + radiance → Profhilo
• Overall skin rejuvenation → Both

Neither treatment is automatically better for every patient.

What Results Can You Expect?

Both treatments aim to improve skin quality rather than create dramatic facial volume.

Rejuran is commonly selected for:

• Skin texture
• Elasticity
• Fine lines
• Overall skin quality

Profhilo is commonly selected for:

• Hydration
• Elasticity
• Skin firmness
• Fine lines and overall skin quality

Results develop gradually, and individual outcomes vary depending on skin condition, treatment protocol, injection technique, and individual response.

How Much Do They Cost in Korea?

Prices vary depending on the clinic, product, treatment amount, and treatment area.

In general:

• Rejuran → Often priced by cc
• Profhilo → Often priced per syringe or treatment session

When comparing prices, check the exact product, amount, treatment area, and whether VAT is included.

What About Downtime?

Both treatments involve injections, so temporary side effects can occur.

Possible effects include:

• Redness
• Swelling
• Bruising
• Tenderness
• Small temporary bumps

Recovery varies depending on the injection technique, treatment area, and individual response.

What Should Foreigners Check Before Booking?

International patients should confirm:

• Exact product and formulation
• Amount used
• Treatment area
• Injection technique
• Total price and additional fees
• Who performs the injections
• Expected downtime and aftercare

It is important to compare the same product and treatment amount rather than relying on advertised prices alone.

Can You Combine Rejuran and Profhilo?

Yes. Some clinics may combine both treatments when patients have different skin-quality concerns.

For example:

• Rejuran + Profhilo → Skin quality + hydration
• Rejuran + lifting treatment → Skin quality + firmness
• Profhilo + lifting treatment → Hydration + tightening

However, combining treatments is not automatically better. The plan should be customized according to your skin condition, treatment goals, and recovery needs.



Final Thoughts

Rejuran and Profhilo are both popular injectable skin treatments in Korea, but they have different strengths.

• Rejuran = skin quality and elasticity
• Profhilo = hydration and elasticity
• Rejuran = PN-based treatment
• Profhilo = hyaluronic acid-based treatment
• Rejuran = texture and fine lines
• Profhilo = hydration, firmness, and overall skin quality

When comparing Rejuran vs Profhilo, consider whether your priority is improving skin texture and elasticity or boosting hydration and overall skin quality.