Rejuran + Botox: Can They Be Combined?

September 9, 2026

Rejuran + Botox: Can They Be Combined?

Rejuran and Botox are popular aesthetic treatments in Korea that address different aspects of facial aging. Rejuran focuses on skin quality and elasticity, while Botox reduces targeted muscle activity and dynamic wrinkles.


What Is Rejuran?

Rejuran is a polynucleotide (PN)-based injectable treatment designed to support skin quality and regeneration.

Key features:

  • Supports skin elasticity
  • Improves skin texture
  • Helps soften fine lines
  • Supports overall skin quality
  • Usually requires multiple sessions

It is often chosen by patients seeking smoother and healthier-looking skin.


What Is Botox?

Botox temporarily reduces muscle activity by targeting specific muscles.

Key features:

  • Softens dynamic wrinkles
  • Can treat forehead lines and crow's feet
  • May reduce masseter muscle bulk
  • Minimal downtime
  • Results develop gradually

It is commonly used for expression lines and muscle-related facial contouring.


Can Rejuran and Botox Be Combined?

👉 Yes, Rejuran and Botox can be combined in some treatment plans because they target different concerns.

For example:

  • Rejuran → Skin quality and elasticity
  • Botox → Dynamic wrinkles and muscle activity
  • Skin rejuvenation + wrinkle reduction
  • Injectable treatments with different mechanisms

The exact timing depends on the treatment areas, injection technique, and provider's protocol.


Why Combine Rejuran and Botox?

The combination may be useful when patients have both skin-quality concerns and dynamic wrinkles.

Key benefits may include:

  • Rejuran supports overall skin quality
  • Botox reduces excessive muscle movement
  • Fine lines + texture can be addressed together
  • Different treatment goals can be combined

The goal is to complement the treatments rather than use two procedures for the same concern.


Rejuran + Botox: Key Differences

  • Main target: Rejuran → Skin; Botox → Muscles
  • Main focus: Rejuran → Texture and elasticity; Botox → Dynamic wrinkles
  • Treatment method: Both → Injection-based
  • Best for: Rejuran → Skin quality and fine lines; Botox → Expression lines and muscle bulk
  • Results: Both → Temporary and develop gradually

The combination can address several signs of aging at once.


Is the Combination Worth It?

👉 It may be worthwhile when you have both skin-quality concerns and dynamic wrinkles, but not everyone needs both treatments.

For example:

  • Fine lines + rough texture → Rejuran + Botox
  • Forehead wrinkles + poor skin quality → Combination
  • Crow's feet + dry or textured skin → Combination
  • Mainly skin texture → Rejuran may be enough
  • Mainly dynamic wrinkles → Botox may be enough

A professional assessment can help determine whether combining them is appropriate.


What Results Can You Expect?

The treatments have different goals.

Rejuran may help with:

  • Skin texture
  • Elasticity
  • Fine lines
  • Overall skin quality

Botox may help with:

  • Forehead lines
  • Crow's feet
  • Other dynamic wrinkles
  • Masseter muscle bulk

Individual results vary depending on skin condition, Rejuran amount, Botox dosage, injection technique, and individual response.


How Much Does Rejuran + Botox Cost in Korea?

The combination generally costs more than receiving either treatment alone.

In general:

  • Rejuran → Usually priced by cc
  • Botox → Usually priced by units or treatment area
  • Combination → Higher total cost

The final price depends on the Rejuran formulation and amount, Botox brand and dosage, treatment areas, and clinic.


What About Downtime?

Both treatments generally involve limited downtime, but temporary injection-related effects can occur.

Possible effects include:

  • Small bumps
  • Redness
  • Swelling
  • Bruising
  • Tenderness

Rejuran may cause more visible temporary bumps because of the injection technique, while Botox typically causes small injection-site effects.


How Should Rejuran and Botox Be Scheduled?

Both treatments may be performed during the same treatment period, depending on the provider's protocol.

Your provider may consider:

  • Treatment areas
  • Injection depth
  • Product amount
  • Botox dosage
  • Skin condition
  • Recovery needs

Do not assume that same-day treatment is appropriate for every patient.


What Should Foreigners Check Before Booking?

International patients should confirm:

  • Exact Rejuran product and cc
  • Botox brand and units
  • Treatment areas
  • Whether both can be performed during the same visit
  • Total price and VAT
  • Who performs the injections
  • Expected downtime
  • Aftercare instructions

This is especially important when planning a short trip to Korea.


Can You Add Other Treatments?

Yes, but adding more procedures is not automatically better.

For example:

  • Rejuran + Botox + Ultherapy → Skin quality + wrinkles + lifting
  • Rejuran + Botox + skin booster → Skin quality + wrinkles + hydration
  • Rejuran + Botox + laser → Skin quality + wrinkles + skin tone

Any combination should be customized according to your skin condition, treatment goals, and recovery needs.



Final Thoughts

Rejuran and Botox can be combined because they target different aspects of facial aging.

  • Rejuran = skin quality and elasticity
  • Botox = dynamic wrinkles and muscle activity
  • Rejuran = texture and fine lines
  • Botox = expression lines and muscle bulk
  • Combination = skin rejuvenation + wrinkle reduction
  • Both = generally limited downtime

When considering Rejuran + Botox in Korea, focus on your specific concerns and confirm the products, dosage, treatment areas, timing, total cost, and aftercare with a qualified provider.

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